The main focus of this research work was to develop a matrix type transdermal patch containing Propranolol hydrochloride and combination of two hydrophobic Polymers Eudragit L-100 and Eudragit S-100 by Solvent Evaporation technique.Combination of two Plasticizers Glycerine and Dibutyl phthalate were used and their effect on drug release was studied by changing their concentration in each batch.Methanol and Dichloromethane solvent system was used in which methanol acts as a penetration enhancer.Since oral bioavaibility of Propranolol Hydrochloride is poor due to high first pass metabolism...

Stability indicating RP-HPLC method for estimation of Tenofovir Disoproxil Fumarate in the presence of its degradation products during conduction of stability studies on the pure drug which was carried out by using a mobile phase comprising ACN: Water (70:30 v/v), pH adjusted to 4.5with OPA, at flow rate of 1 ml/min. with UV detection at 260 nm. The concentration of TDF was found sufficient for obeying Beer's law over a range of 10-90 g/ml. In the present study, the drug was subjected to acid (0.1N HCl and 0.01N HCl), and alkaline (0.1N NaOH and 0.01N NaOH) hydrolysis. TDF was found to be...

The cleaning processes used in pharmaceutical operations have achieved an increasing emphasis in the past decade both by the regulatory agencies and industry itself. At this time it is generally regarded as just as critical to have effective cleaning processes as to have consistent, validated manufacturing processes. Several developments have caused this emphasis on the cleaning process. First, the new generation of products (as well as those in the current "pipeline") tends to be more potent (e.g., many are potent in mg and sub-mg doses). Second, a series of tragic contaminations occurred...