Due to larynx vital role in phonation, respiration and deglutition the study main purpose was to preserve its functions and to assess the therapeutic option for bicordal-commissure laryngeal glottic cancer. Histopathological, histochemical and immunohistochemical morphologic exam represents an essential stage in diagnosis, resection margins and prognosis evaluation. A multimodal approach of bicordal-commissure glottic carcinoma from the clinic to the lab and beyond is necessary because it represents a complex disease due to the evaluation, diagnosis, staging, treatment indications and...

Cancer is currently the most common human condition and has exceeded cardiovascular disease in terms of specific incidence and mortality in the last two years. Ovarian cancer has been known for a very long time as unpredictable in terms of the natural evolution. There are virtually unknown 'standard' progression and metastasis models as well as a differential and often inconsistent response to the adjuvant anti-cancer therapy. These uncertainties may be explained by insufficient knowledge of the expression of cell growth factor, of the tumor microenvironment and perhaps not least, of...