Peptic ulcer disease (encompassing gastric ulcer and duodenal ulcer) disease affects a large portion of the world population. This occurs due to an imbalance between offensive and defensive factors. Helicobacter pylori infection is recognized as the leading cause of ulcer in the world, particularly in non developed countries, it comes under offensive factors and other agents such as alcohol and non steroidal anti-inflammatory drugs gain importance in developed countries comes under defensive factors. Nowadays the main line of approach in the treatment of peptic ulceration is the eradication...

Silica induced lung fibrosis otherwise known as Silicosis. It is irreversible fibrosis of the lungs caused by inhalation of free silica dust. It is estimated that about million of people are working in various types of mines, ceramics, potteries, foundries, metal grinding, stone crushing, agate grinding, slate pencil industry etc., and occupationally exposed to free silica dust and are at potential risk of developing silicosis. Silica induces different kinds of pro-inflammatory cytokines that help in progression of disease. IL-6 is one of the pro-inflammatory cytokines that produce after...