Transdermal drug delivery systems are adhesive, dug containing devices of defined surface area that deliver a pre-determined amount of drug to the surface of intact skin at a pre-programmed rate. These systems provide drug systemically at a predictable rate and maintain the rate for extended periods of time. In this work an attempt was made to formulate and evaluate TDDS for sustained release Atorvastatin calcium by solvent casting method. Low molecular weight, good permeability of Atorvastatin calcium made it a suitable drug candidate for the development of transdermal patches. The main...

Sustained release drug system is any drug or dosage form modification that prolongs the therapeutic activity of the drug. Ideally a sustained release oral dosage form is designed to release rapidly some predetermined fraction of the total dose in to GI tract. This fraction (loading dose) is an amount of drug, which will produce the desired pharmacological response as promptly as possible and the remaining fraction of the total dose (maintenance dose) is then release at a constant rate. The rate of the drug absorption from the entire maintenance dose into the body should equal to the rate of...

Melt-In-mouth (MIM) technology is an innovative technology, which allows tablet to disintegrate rapidly, usually in a matter of seconds, without the need for water, providing optimal convenience to the patient. Topiramate is antiepileptic drug prescribed extensively for the patient of partial onset seizures, or primary generalized tonic-clonic seizures in both children and adults, is extremely bitter resulting in poor patient compliance. Recently, a number of novel techniques for bitterness inhibition in formulations intended for pediatric and geriatric patients need acceptable taste. In the...

Novel drug delivery systems (NDDS) have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Delivery of drugs directly to targeted sites of action provides several advantages over non-specific delivery of drugs. Oral colon targeted drug delivery system is one of that NDDS which directly deliver a drug in to the colon for local treatment of a variety of colonic diseases as well as systemic absorption of proteins and peptides. The Metronidazole is the drug of choice in the treatment of the diseases like Amoebiasis, Giardiasis,...

This book is simple but the effort for understanding and applying principles of Novel Drug Delivery System by making Phytosomes from herbal plant. We sincerely hope that this book will be helpful to student as well as industry and academic professionals involved in pharmaceutical and other related science. The present study was carried out to preparation and characterization of phytosomes of Prosopis cineraria. Prosopis cineraria evaluate for its Pharmacognostic, Phytochemical and prepared Phytosomes also to evaluate it for antioxidant activity.