The study in this book modified a model of malaria formulated by Tumwiine et al. (2007) by including a vaccination parameter as a new control strategy for the spread of malaria. The aim is about choosing new option or direction using an analytical and experimentally structured approach towards preventing and eradicating malaria in our society. In consideration of the findings of the study, we recommend that a combination of treatment and vaccination rates should be maintained at 0.7 level minimum, in order to eradicate malaria in the population at large.