Cardiovascular autonomic neuropathy (CAN) as an impairment of cardiovascular autonomic regulation is one of the earliest complications of diabetes mellitus. In complex etiopathogenesis of CAN persistent hyperglycemia, genetic predisposition, immunologic and epigenetic factors play role. Presented work is focused on null/wild gene polymorphisms of glutathione S-transferase (GST) M1 and T1. GST enzymes are involved in the degradation of various exogenous and endogenous compounds including organic hydroperoxides (protecting cells from peroxide-induced cell death), in the synthesis of...