The age-adjusted prevalence of obesity in the United States was 30.5 percent in 1999-2000. Although obtaining a precise estimate of the change in the prevalence of obesity over time is difficult because of changing definitions, nearly all clinical authorities agree that obesity is reaching epidemic proportions. In response, pharmacological and surgical treatments for weight loss have become both more numerous and more commonly used. This report reviews the evidence on such treatments in adults, adolescents, and children. We assess the efficacy and safety of the following medications used for...