This book is concerened with studying the oxidation of 3-acetyl-4-hydroxyquinolin-2(1H)-one via selenium dioxide. The first chapter was introduced the synthesis and chemical reactivity of acetylquinolinone. Then, the second chapter is divided to Study the oxidation reaction and show the chemical reactivity of - keto acid with different reagents. The third chapter is showed the thermal Study for -keto acid and ester followed by in fourth chapter; the biological activity for different compound. Afterwards, in five chapter, there were chemistry and biochemistry experimental. Finally conclusion...