The need for new, safe and more effective antimicrobial is a major challenge to the pharmaceutical industry today, especially with the increase in opportunistic infections. The discovery of antibiotics had a major impact on the control of infectious diseases and the development of pharmaceutical industry. Screening of microorganisms for the production of novel antibiotics has been intensively pursued for many years. The Streptomycetes are the producers of more than half of the 10,000 documented bioactive compounds which have offered over 50 years of interest to industry. In view of all the...