The nicotinamide coenzymes and CoA play an important role in the metabolism of lipids as in -oxidation of fatty acids and ketone body formation. The suggested function of NADH and CoA diphosphatases are: regulation of the size of CoA and nicotinamide coenzyme pools in different subcellular compartments, elimination of non-functional oxidized CoA and NAD+/NADH which may accumulate in the oxidizing environment of the peroxisomes and mitochondria, where there is a high level of oxidative stress. NADH diphosphatases are the only source for generation of NMNH inside the cell. The presence of...