Extended spectrum beta lactamases are rapidly evolving group of beta lactamase enzymes produced by enterobacteriaceae species. These extended spectrum beta lactamases (ESBL) have high resistance to the wide variety of antibiotics that are mostly used in hospitals where there has been increased concern over infections caused by E.coli. Totally 90 clinical isolates of E.coli were collected from local Government Hospital during Jan 2008 to April 2010. All suspected isolates were screened by disk diffusion synergy method and subsequently isolates showed the presence of ESBL were subjected to...