Hyperglycemia results in excessive production of free radicals which leads to sever oxidative damage of the cell components like lipids, proteins and DNA. These radicals attack the polyunsaturated fatty acids in the cell membrane leading to disturbances in membrane structure and properties such as membrane permeability, integrity and also the binding of insulin to its receptors that is embedded in the cell membrane, Thus it was found that membrane enriched in unsaturated fatty acids tends to bind more insulin than membrane enriched in saturated fatty acids, and the membrane components may be...

Diabetes mellitus and hypertension represent major causes of chronic kidney diseases and initiation of dialysis; In addition, glomerular diseases, malnutrition, infectious diseases, and acute kidney injury can progress to end-stage renal disease, contributing to the increased global burden of death associated with this condition. Current treatment modalities often fail to target the major underlying contributors for progression of renal disease. Indications for kidney transplantation have expanded considerably in terms of recipient age, primary disease leading to end-stage renal failure, and...

Our diet contains a complex mixture of fats and oils whose basic structural components are fatty acids. We generally consume at least 20 different types of fatty acids which are classified as saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA). The types of fatty acids in our diet determine the types of fatty acids that are available to the composition of cell membranes which carry out many functions that are necessary for physiological health. Increased dietary intake of omega-6 leads to production of prostaglandins, thromboxanes and leukotrienes and interferes...