This volume assembles reviews on topics in two major related areas. One of these concerns the interactions of cells with substrata and with other cells, which are mediated by the extracellular matrix and soluble molecules. As described in this volume, these interactions are responsible for controlling cell functions ranging from embryogenesis and neural development to blood clotting. More- over, important properties of the extracellular matrix can be modulated by the interdependent actions of tumor cells and fibroblasts. The other major area of interest concerns the response of cells to...