Specific biomolecular interactions occur in practically every bio logical process, usually involving macromolecules such as proteins and nucleic acids. Thus, it is not surprising that great attention has been devoted by biologists, chemists, and physical chemists to the general phenomenon of macromolecular recognition in order to gain a better understanding of the principles, forces, and energetics that de termine the often remarkable specificities of such interactions as those of enzymes and their substrates and inhibitors, antibodies with anti gens, hormones with their receptors, and DNA...