Historically, the major emphasis on the study of purinergic systems has been predominantly in the areas of physiology and gross pharmacology. The last decade has seen an exponential in crease in the number of publications related to the role of both adenosine and A TP in mammalian tissue function, a level of interest that has evolved from a more molecular focus on the identity of adenosine and A TP receptor subtypes and the search for selective ligands and development of radioligand binding assays by Fred Bruns and colleagues (especially that for A receptors) that played z a highly...

The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black's H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research...

IN THIS book an attempt is made to describe briefly and accurately the main outlines of the organized system by means of which the Catholic Church carries on its work in the world today. Only the most elementary summary of this tremendous subject is possible within the limits of a single volume, not meant for ecclesiastical students, but for the average reader, whether Catholic or non-Catholic, who would like to know in a general way how the Church is constructed and how its various parts are put together to function within the framework of the institution as a whole. There are a multitude of...