This book constitutes the refereed proceedings of the 6th bi-annual Latin American Conference on Human-Computer Interaction, CLIHC 2013, held in Guanacasta, Costa Rica, in December 2013. The 11 full papers and 14 short papers were carefully reviewed and selected from 32 submissions. The papers address all current topics in HCI such as: cultural issues, assistive technologies, usability, accessibility, multimodal inter-faces, design issues, HCI education, and visualization and evaluation techniques, among others.