The Framework for Post-Phylogenetic Systematics reframes biological systematics to reconcile classical and cladistic schools. It combines scientific intuition and statistical inference in a new form of total evidence analysis developing a joint macroevolutionary process-based causal theory. Discrepancies between classical results and morphological and molecular cladograms are explained through heterophyletic inference of deep ancestral taxa, coarse priors leading to Bayesian Solution of total evidence, self-nesting ladders that can reverse branching order, and a superoptimization protocol...