Sedative class of drugs, exemplified by the barbiturates, has been used for the relief of anxiety and the induction of sleep since about 1903. Barbiturates are recognized to be the most important sedative hypnotic drugs. These drugs used mostly to feel relaxation and analgesia. Business men, civil servants, parents and so on; use these drugs to relieve the tension of modern life. Phenoparbital is one from this family of drugs.With large doses, respiration is progressively depressed. In the deeply anesthetized patient, shock may occur as a result of vasomotor depression.Occasionaly, the...

Doxorubicin (DOX) is an anticancer drug, used to cure lung cancer in spite of its side effect on the heart. The present study assessed the efficacy of black seed (BS) in treatment of the induced pathological alterations in heart of white albino mice following the injection with the anticancer drug DOX. Data showed the immunomodulatory effect of BS resulted in improvement in lung and heart tissues incurred lesions, and decreased the cytokeratin expression in lung tissues.

Lindane (gamma hexachlorohexane) is the most toxic of all the isomers of hexachlorohexane and has powerful insecticidal properties and it is used for the control of insects of field crops and pests in houses. One of the main routes of human exposure is food contamination where its residues has been found in water, milk, cooking oil and fisH. In the liver, lindane is thought to act by interfering with hepatic oxidative capacity and glutathione metabolism. The first goal of this study; was to explore the histopathological effect of lindane in the heart, and role of CK and ET-1 in heart toxicity...