The most promising method for enhancing solubility, therefore promoting the rate of dissolution is the formation of liquisolid compacts. With Liquisolid technique as described by Spireas liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders, by simple physical blending with selected excipients named the carrier and the coating material. The liquid portion can be a liquid drug, a drug suspension or a drug solution in suitable non-volatile liquid vehicles. Once the carrier is...

Amlodipine is a long-acting calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. Like other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure; in angina, it increases blood flow to the heart muscle. It has poor water solubility, thus exhibiting the problem of variable bioavailability. With Liquisolid technique liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into...

Performance based on open skills may be more influenced by anxiety and self-confidence than performance based on closed skills. An open skill can involve either an individual or team sport with the athlete per- forming in an interactive and ever-changing environment (basketball, tennis). A closed skill is performed in a more stable environment that is relatively predictable and often self-paced (i.e., golf, gymnastics, crew teams). Anxiety may have a different impact on performance on these two types of skills, based on how the influence of the environment and other competitors potentially...

I marvel at a woman's unending and repeatedly renewed struggle throughout her life. To capture, to explore and to analyze all that went into the creation and aesthetic beautification of these women, I scanned my own chaptered life as a daughter, a wife and a mother to involve instinctive sensitivity, subjectivity and objectivity without any preset conviction or bias. Tolerance, love and welfare of family are the crux of a womans way of feeling blessed. How the women characters would have reacted, behaved and survived tough dos and dont's needs to be understood and saluted at. Even after three...