The reactive nitrogen species peroxynitrite is a product of the reaction of nitric oxide with superoxide. This powerful oxidant has been proposed to contribute to the pathology of a large variety of diseases associated with increased inflammation and cancer development by its ability to oxidize and nitrate a variety of macromolecules. The transcription factor NF- B is a predominant player in inflammatory and carcinogenic processes and has been found to play a major role in the transition from chronic inflammation to cancer initiation. In this study the molecular mechanisms by which NF- B is...