This book describes analytical models and estimation methods to enhance performance estimation of pipelined multiprocessor systems-on-chip (MPSoCs). A framework is introduced for both design-time and run-time optimizations. For design space exploration, several algorithms are presented to minimize the area footprint of a pipelined MPSoC under a latency or a throughput constraint. A novel adaptive pipelined MPSoC architecture is described, where idle processors are transitioned into low-power states at run-time to reduce energy consumption. Multi-mode pipelined MPSoCs are introduced, where...