Escherichia coli is a gram negative normal inhabitant of human gut in large intestine. E.coliis responsible for three types of infections in humans: urinary tract infections (UTI), neonatal meningitis, and intestinal diseases (gastroenteritis). The dense bacterial consortium, called "microbiota" that inhibits the intestinal tract,playing a vital role in human health and diseases Cancer. Recent ground breaking discovery by Jobin group ( unveiled that E.coli NC101 strains of B2 phylotype widely known as commonsal cause to promote colon cancer. We also discussed other gut flora also play ...