Scrapie is a unique disease whose etiology is through protein infection rather than a biological agent. Genetic polymorphism at 136, 154 and 171 codons provide the susceptibility/ resistance to the disease outbreak. PCR-SSCP has been found to be a robust technique for the identification of genetic variants because of SNP in the ORF (open reading frame) of PRNP gene efficiently at low cost, evidenced by novel DNA sequences resulted from the SSCP variants. Prevalence of susceptible alleles at 136, 154 and 171 codons however did not result into the scrapie disease clinical symptoms in indigenous...