With the drastically change in climatic conditions in recent years, demand for air conditioning is spreading all over the world. This causes a primary consumption of energy in high quantity. In order to provide the best indoor air quality and thermal comfort with minimum consumption of energy, the hybrid desiccant cooling system is one of the options in our daily life. This work presents results of experimental and simulation study of a hybrid desiccant cooling system for air conditioning applications using two different desiccants (Lithium chloride and Calcium Chloride).