Conventional dosage forms often lead to wide swings in serum drug concentrations. Most of the drug content is released soon after administration, causing drug level in the body to rise rapidly, attain maximum concentration and then decline sharply. This sharp fluctuations often cause unacceptable side effects at the peaks, followed by inadequate therapy at the troughs. In the transdermal drug delivery system, drug is released at a constant rate and provides plasma concentration that remains constant over an extended period of time. In the present work, chitosan film has been used as rate...
Conventional dosage forms often lead to wide swings in serum drug concentrations. Most of the drug content is released soon after administration, caus...