It was reported earlier that the exogenous BMP-2 treatment of two different primary fibroblastic cultures, each derived from a primary prostate tumor of the Pten null mouse model, results in enhanced secretion of SDF-1, a chemokine that functions as both chemoattractant for cell migration and mitogen for cell proliferation and survival. In the current study, we expanded the primary tumor or AD tumor CAF cultures by five more in number to determine how consistent the observed effect of BMP-2 is. While there is indeed a consistent enhancement of SDF-1 induction in all AD-CAF cultures, the...