Cancer is a major health problem worldwide and is one of the most prominent causes of morbidity and mortality in children and adults causing about 9 million deaths annually. The success of novel cancer therapies depends on the identification of functional targets that play an essential role in tumor growth and metastasis, survival and evasion from immunosurveillance. Costimulation through CD80 or through CD28-bearing T cells, regresses the growth in B cell lymphomas retard the proliferation and induce apoptosis. On the other hand Tuberculosis(MTB) a major infectious disease is becoming global...