In present research work, dispersible tablets of cefpodoxime proxetil were formulated using dry granulation technique. Cefpodoxime proxetil is an advanced-generation, broad-spectrum cephalosporin antibiotic. Cefpodoxime proxetil has slightly bitter taste and has poor water solubility. So in case of acute bacterial exacerbation of chronic bronchitis (AECB) groupA beta-hemolytic streptococcal pharyngotonsillitis, and uncomplicated skin/skin structure infections it require immediate release of drug from the dosage form, which make Cefpodoxime Proxetil suitable candidate for dispersible tablets.

Manufacturing area with new equipment having high capacity compared to previous one (Production Line) i.e. FBD, RMG, Co Mill and Container Mixer. Manufacturing of Metformin ER 500mg tablets is planned to do in new area with new equipment. As the size and capacity of the equipments are bigger than previous equipments, batch size of Metformin ER tablets is increasing from 0.4 mio to 0.6 mio. As the production in new area and new equipment, qualification of area, equipment, water and air was carried out as per qualification protocol. Now, further the process of optimization was performed for...

I had studied development aspects of sustained release microspheres of Diclofenac sodium that release the drug Up to 24 hour and improve Bioavailability of Diclofenac Sodium by using spray drying and simple solvent evaporation technique.Preparation of Chitosan Microsphere with Diclofenac Sodium by various techniques such as spray drying and simple solvent evaporation technique. For Spry Drying technique the optimization of Spry Dried Parameter such as inlet Temperature and Feed pump Rate. Optimization of Temperature by taking the 130 degree C, as a starting Temperature and showing the...