The uniqueness of human architecture is based on interlinkages of the regulatory systems -neural, endocrine, immune, genetic- but the molecular mechanisms underlying this network are still incompletely understood. The endogenous indolergic system is considered as a protein-neuro-humoral-endocrine informational network resulted from the chemical and biological structure of some endogenous biomolecules with indole structure such as tryptophan, serotonin and melatonin. The endogenous privileged structures, such as the indole nucleus, can be used to develop active biological/therapeutic medical ...