Antibiotics resistance is one of the biggest challenges facing global public health. In the past sixty years, many classes of antibiotics have been developed, but duration of benefit appeared to be limited: resistance has emerged to every antibiotic class. Antibiotic resistance seriously hampers treatment of infections and leads to increased length of stay, morbidity, mortality and healthcare costs, both in hospital and community settings. In the era of increasing bacterial resistance and in the absence of new effective antibacterial drugs, it is necessary to use the currently available...