Acyclovir conventional tablets have been used for long period for the treatment of viral infections. When orally administered, it is showing slow and incomplete absorption from gastrointestinal tract. The total oral bioavailability of acyclovir is between 15-30% due to poorly soluble drug and short plasma half life (3 Hrs). Oral bioavailability of acyclovir can be achieved by improving the solubility and dissolution rate. Several techniques have been used to improve the solubility and dissolution rate of acyclovir such as solid dispersions and spherical agglomerates and complexes. Co-...