In this research work an attempt was made to prepare once a day formulation of gliclazide. The purpose was achieved by making mucoadhesive microcapsules of gliclazide. A combination of polymers, sodium alginate, sodium Carboxy Methyl Cellulose, hydoxy propyl methyl cellulose and carbopol 934P was utilized for this purpose. The formulation was prepared and optimized and evaluated for in-vitro and in-vivo performance. The results obtained were very satisfactory.

The objective of present work was to develop a "tablets in capsule" system for facilitating both immediate and pulsatile drug deliveries of theophylline to mimic the circadian rhythm of nocturnal asthma. The system comprised of capsule filled with two tablets, first pulse and second pulse tablet prepared by wet granulation method. First pulse tablet was not coated and was responsible for providing loading dose whereas; second pulse tablet was coated with Eudragit L100 and Eudragit S100 to release drug in colon after specific lag time. Two independent variables, amount of polymers and coating...