In this research work an attempt was made to prepare once a day formulation of gliclazide. The purpose was achieved by making mucoadhesive microcapsules of gliclazide. A combination of polymers, sodium alginate, sodium Carboxy Methyl Cellulose, hydoxy propyl methyl cellulose and carbopol 934P was utilized for this purpose. The formulation was prepared and optimized and evaluated for in-vitro and in-vivo performance. The results obtained were very satisfactory.

This book is a description of anti-diabetic activity of Spheranthus Indicus on streptozotocin induced diabetes on rats. Sphernathus Indicus which is commonly known as Gorukhmundi is a weed of Indian origin whose various activities have been proven in Charak Sahinta.The mortality rate with streptozotocin was quite low as compared to alloxan induced diabetes.The response in lowering blood sugar in fasting as well as post postprandial rats along with the lipid profile like triglycerides, LDL, VLDL with Spheranthus Indicus is quite positive. This book can be used as good resource for designing a...