This research focuses on the NP-Hard problem of finding an optimal tree topology where leaves represent biological sequences. The problem tries to minimize the number of changes between sequences. As there number increases, the search space size grows exponentially, requesting the use of optimization methods, to come up with an acceptable optimal topology. Despite the efforts to relate large number of species and gene families to each other, the computation intensive load of many popular methods for evaluating trees (ex: parsimony and maximum likelihood) establish the quasi-inexistence of an...