N-Arylhydroxamic acids are drug like molecules. Biological activity always depends upon physico-chemical property namely lipophilicity, which has direct impact on the potency of the molecule. Partition coefficient is a measure of how well a substance partitions between a lipid and water.The partition coefficient has a strong influence on ADME properties of molecules. Both of these parameters are important factor in QSAR.

The aqueous solubility of drugs plays a key role in pharmaceutical, environmental and biological processes. It is an important factor in the ADMET (absorption, distribution, metabolism, elimination and toxicity) research. Since the experimental determination of water solubility is time-consuming therefore, reliable computational predictions are used for the pre-selection of acceptable drug like compounds. The Partial Least Squares (PLS) regression is a statistical method that bears some relation to principal components regression. PLS finds a linear regression model by projecting the...

Hydrophobic character, logP is a physico-chemical property of solute. Knowledge of this hydrophobic character plays an important role to decide the solutes' ability to interface with biochemical systems. It is the measure of the ease with which drug penetrate membranes and bind to lipophilic surface. N-arylbenzohydroxamic acids is drug like molecules it act as anticancer, antiviral, antibacterial etc. and their hydrophobic nature play important role in drug development.