"Lysosomes are now known tobe notjustacollectionofisolatedorganellesofin- terest only to the biochemist, but part ofa complex, dynamic, membranous sys- tem essential to the cell's economy." So wrote the late Dame Honor Fell and I in the preface to the first volume of Lysosomes in Biology and Pathology almost 30 years ago. We wentonto say thatresearchonthelysosomalsystematthetimewas in a state ofexplosive and chaotic growth. While the chaos has beenlargely reduced, the growthofresearch into the bi- ology ofthe lysosome remains considerable. Biologists worldwide are still fasci- nated by the...