"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray...

The book provides a synthetic and exhaustive view of how proteins have evolved their structure to accommodate a variety of metal ions in order to accomplish the most demanding chemical reactions that sustain life. This book may be the subject of a monographic course on its own or may complement bioinorganic chemistry textbooks to obtain a comprehensive view of the structural aspects of this subject. It is directed at advanced undergraduate and graduate students, researchers, instructors, and professors teaching in protein science, biochemistry, cell biology. This is the first textbook...

The book provides a synthetic and exhaustive view of how proteins have evolved their structure to accommodate a variety of metal ions in order to accomplish the most demanding chemical reactions that sustain life. This book may be the subject of a monographic course on its own or may complement bioinorganic chemistry textbooks to obtain a comprehensive view of the structural aspects of this subject. It is directed at advanced undergraduate and graduate students, researchers, instructors, and professors teaching in protein science, biochemistry, cell biology. This is the first textbook...

This book examines the present and future of drug discovery at protein-protein interfaces. It details computational and experimental tools used in the field, and offers examples of drug-like molecules effective in interacting at protein-protein interfaces.