This edited volume describes the spatial diffusion of knowledge and innovation using a large dataset at the regional level, and presents scientific evidence on the role of knowledge and innovation on regional development. The empirical results support a new design for innovation policies at the regional level, which could help the European Union to achieve the targets set up in its 2020 Agenda. Today, financial capital, general information, consolidated technologies and codified knowledge are readily available virtually everywhere. However, the ability to organize these 'pervasive' factors...