This monograph by Antonino Germano and Francesco Tomasello with contributions of Giuseppe Anastasi, Placido Bramanti, and Domenico d'Avella, constitutes a comprehensive, yet focused overview of those blood brain barrier permeability changes and related damaging sequelae associated with the presence of subarachnoid blood commonly linked to aneurysmal bleeding. As noted by the authors, despite improvements in the surgical and clinical management of aneurysms and their associated bleeding, these patients still experience an unacceptably high morbidity and mortality linked to the presence of...