Twenty years have elapsed since cytoplasmic proteins exhibiting high-affinity binding of long-chain fatty acids were first identified (Ockner et al., Science 177:56-58, 1972). These cellular fatty acid-binding proteins (FABPs) are now well established to comprise a ligand-defined group of macromolecules belonging to a family of cytoplasmic lipid binding proteins. Unique features of the FABPs are the existence of distinct types of FABP and that these are found in a variety of tissues in remarkable abundance, with some cells expressing more than one type. The physiological significance of the...
Twenty years have elapsed since cytoplasmic proteins exhibiting high-affinity binding of long-chain fatty acids were first identified (Ockner et al., ...
The discovery of the second-messenger functions of on serine and threonine residues. Although there is inositol 1,4,5-trisphosphate (Ins(1,4,5)P 3) and 1,2-dia general agreement that PKC plays an important role in cylglycerol (DAG), the products of receptor-stimulated the initiation and/or modulation of receptor-linked re phosphatidylinositol 4,5-bisphosphate (PtdIns( 4,5)P ) 2 sponses, the precise nature or molecular details of this hydrolysis, marked a turning point in the studies on the involvement remain elusive. There are several sugges mechanisms of mediation of functional hormone and...
The discovery of the second-messenger functions of on serine and threonine residues. Although there is inositol 1,4,5-trisphosphate (Ins(1,4,5)P 3) an...
