During development, attractive and repulsive guidance molecules, such as semaphorins, are responsible for proper wiring of axons and dendrites. Attractive and repulsive external guidance cues bind to receptors which activate intracellular signalling pathways and reshape the growth cone. The role of vesicular traffic in axonal guidance is still largely unknown. Vesicular traffic requires SNAREs proteins for membrane fusion. The exocytic vesicular SNARE Synaptobrevin2 mediates neurotransmitter release in mature neurons while TI-VAMP is mainly known for mediating axon growth. Their potential...
During development, attractive and repulsive guidance molecules, such as semaphorins, are responsible for proper wiring of axons and dendrites. Attrac...
