In the present investigation, novel pyrazoles and pyrrolo[3,2-c]pyridines have been designed as potential antiproliferative agents against different types of cancer. Their antiproliferative activities were examined against 61 cancer cell lines of 9 different cancer types. Biological investigation of representative target compounds at molecular level was conducted in order to investigate the possible mechanism(s) of antiproliferative activity of our target compounds. In addition, molecular modeling study was carried out. Some compounds showed broad-spectrum antiproliferative activity, while...
In the present investigation, novel pyrazoles and pyrrolo[3,2-c]pyridines have been designed as potential antiproliferative agents against different t...