Beta Amyloid peptide (Aβ), specifically Aβ (1-42) is toxic to neurons and is hence strongly associated with loss of brain function through the course of Alzheimer's disease. This deposition induces neuronal death and apoptosis. Extensive studies in recent years have focused on Aβ-mediated microglia activation with regard to secretion of pro inflammatory cytokines such as TNF-α. TNF-α induces two distinct pathways: one of them is apoptosis and the other one is NF-κB activation and eventually cell survival and proliferation.One of the questions that came to us was...
Beta Amyloid peptide (Aβ), specifically Aβ (1-42) is toxic to neurons and is hence strongly associated with loss of brain function through t...
