The development and progression of colonic carcinogenesis are known to be caused by the accumulation of cancer related genetic alterations.These alterations affect the expression of a variety of downstream genes, including those involved in regulating the cell cycle, apoptosis, adhesion, and angiogenesis.p53 overexpression is a late event in colorectal tumorigenesis and can be used as a marker of the risk of malignant transformation of advanced colorectal adenoma.bcl-2 may play an important role in the early stage of the adenoma-carcinoma sequence. PCNA expression is sequentially increased...