This book constitutes the thoroughly refereed proceedings of the 16th East-European Conference on Advances in Databases and Information Systems (ADBIS 2012), held in Poznan, Poland, in September 2012. The 32 revised full papers presented were carefully selected and reviewed from 122 submissions. The papers cover a wide spectrum of issues concerning the area of database and information systems, including database theory, database architectures, query languages, query processing and optimization, design methods, data integration, view selection, nearest-neighbor searching, analytical query...