It was found that mononuclear cells in the lung parenchyma of mice C57BL/6 after intratracheal administration of bleomycin demonstrated mesenchymal phenotype and express surface CD44, CD73, CD90, CD106, but did not express CD31, CD34, CD45. Bleomycin enhances the differentiation of MSCs in the direction of fibroblast cells in vitro and does not change the activity of adipogenic differentiation, at the same time chondrogenesis and osteogenesis are inhibited. Our results demonstrate that intranasal inoculation of pegylated hyaluronidase (pegHYAL), blocks bleomycin-induced lung injury and...
It was found that mononuclear cells in the lung parenchyma of mice C57BL/6 after intratracheal administration of bleomycin demonstrated mesenchymal ph...