Chemoprevention, a relatively new and promising strategy to prevent cancer, is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the process of carcinogenesis. The chemopreventive effects elicited by these natural dietary compounds are believed to include antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest. Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling...

Aceclofenac floating pellets where prepared by extrusion spheronization method and the drug-released profile of aceclofenac was investigated. Different batches of pellets were prepared by using sodium alginate and HPMC K4M, HPMC K100LV as polymer. In vitro dissolution of pellets was carried out in USP apparatus XXIV (paddle method) at 50rpm.The drug release was measured by using UV spectroscopy of max of 273nm for acid buffer media. The dissolution data were treated with zero order, first order and Higuchi model. Half of the formulations were fitted to Higuchi model and to the first order...

The present research was undertaken to investigate the antimicrobial activity of ethanol extract of Pouzolzia zeylanica (L.) Benn. (Family: Urticaceae) as well as to determine the phytochemical, cytotoxicity, antifungal activity of the extracts. In phytochemical screening, it was found that the ethanol extract contains alkaloids, glycosides, tannins and flavonoids. From the present study, it was found that the ethanol extract posseses significant cytotoxic activity with the LC50 value of 6.1 μg/ml and the LC90 value of 12.2μg/ml. The antibacterial activity of the ethanol extract...