Artificial biomaterials are being used for the treatment of various diseases since the past two millenniums. Synthetic bone grafts have gained acceptance as popular functional biomaterial substitutes. However, the concerns on the possible toxic effects produced by these bone substitutes in the human body are continuing. As such, it becomes imperative that the genotoxicity of these bone substitutes be assessed prior to commercialization. Evidently, there is no single test for ascertaining the complete lack of genotoxicity. On the other hand, it appears redundant to carry out all the...