Hyperlactatemia is a side effect associated with use of anti-retroviral therapy. This study aimed at establishing the prevalence and determinants of hyperlactatemia among patients on combination ART in resource limited settings. The study found a high prevalence of hyperlactemia in this cohort of patients. The associated risk factors for this condition included: Stavudine based regimen, use of ART for more than 24 months, low CD4 count, obesity among others. Clinical presentation was found to be nonspecific hence unreliable in making the diagnosis. Hepatomegaly was found to be quite specific...