The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the...
The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved be...
A simple, fast and precise (RP-HPLC) reversed phase high performance liquid chromatographic method is developed for the determination of Nitazoxanide. The linearity of Nitazoxanide was found in the range of 50 to 150 g/ml. The recovery was calculated by standard addition method. The average recovery was found to be 99.81% for our product. The proposed method was found to be accurate, precise and rapid for determination of Nitazoxanide."
A simple, fast and precise (RP-HPLC) reversed phase high performance liquid chromatographic method is developed for the determination of Nitazoxanide....
